Prof. Dr. med. Nikolai Hopf
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Kernkompetenzen
  • Minimal Invasive Neurochirurgie
  • Endoskopische Neurochirurgie
  • Neuroonkologie – Behandlung von Hirn- und Schädelbasistumoren
  • Vollendoskopische transnasale Behandlung von Hypophysentumoren
  • Vaskuläre Neurochirurgie – Behandlung von Aneurysmen, Cavernomen, AV-Malformationen
  • Bypass-Chirurgie am Gehirn
  • Hirnnerven-Kompressionssyndrome (Trigeminusneuralgie, Facialisspasmus, Vestibularisparoxysmie)
  • Liquorzirkulationsstörungen – Behandlung von Hydrocephalus und Zysten
  • Tumore der Wirbelsäule und des Rückenmarks
Beruflicher Werdegang

seit 5/2018
Partner ENDOMIN, Klinik Hirslanden, Zürich, CH

seit 12/2015
Leiter ENDOMIN, Klinik Stephanshorn, St.Gallen, CH

seit 7/2013
Partner RadioChirurgicums / CyberKnife® Südwest, Göppingen, D

4/2014
Gründung NeuroChirurgicum Stuttgart, D

2/2003-3/2014
Ärztlicher Direktor, Neurochirurgische Klinik, Klinikum Stuttgart, D

5/2001
Ernennung zum Universitäts-Professor für Neurochirurgie (C-3)

12/1999-2/2003
Leitender Oberarzt, Neurochirurgische Universitätsklinik Mainz, D Direktor: Prof. Dr. Axel Perneczky

1/2000
Habilitation, Venia legendi im Fach Neurochirurgie Thema: Motilität und Proliferation humaner Gliomzellen in vitro: Analyse mittels kontinuierlicher Einzelzellbeobachtung

1/1997-11/1999
Oberarzt, Neurochirurgische Universitätsklinik Mainz, D

7/1996-12/1996
Facharzt, Neurochirurgische Universitätsklinik Mainz, D

1-7/1996
Forschungssemester: Institut für Neurochirurgische Pathophysiologie, Universitätsmedizin Mainz, Direktor: Prof. Dr. Oliver Kempski

3-6/1993
Studienaufenthalt, Phoenix, Arizona, USA Dr. K. Manwaring: Kinderneurochirurgie: Phoenix Children´s Hospital, Dr. R. Spetzler: vaskuläre Neurochirurgie: Barrow Neurological Institut

5/1990-6/1996
Assistenzarzt, Neurochirurgische Universitätsklinik Mainz, D

6/1991
Promotion mit der Note „summa cum laude“ Thema: Experimentelle Emetin-Myopathie

Schulen, Studium & Diplome

2013
Grundkurs Radiochirurgie am CyberKnife®

2010
Zertifizierung ICH-GCP-konforme Durchführung klinischer Studien

1999
Europäischer Facharzt für Neurochirurgie (EANS)

1994
Amerikanisches Staatsexamen für Medizin (USMLE) II: clincal science

1993
Amerikanisches Staatsexamen für Medizin (USMLE) I: basic science

1989-1990
PJ West Virginia University Hospital, Morgantown, WV, USA

1983-1989
Studium Humanmedizin, Johannes-Gutenberg Universität Mainz, D

Praktiziert bei
  • Klinik Hirslanden – Belegarzt
  • Klinik Stephanshorn – Spitalarzt
  • Endomin – Zentrum für Endoskopische & Minimale Invasive Neurochirurgie
  • Neurochirurgie Ostschweiz
  • Stroke Center Hirslanden
  • NeuroChirurgicum – Zentrum für Endoskopische & Minimale Invasive Neurochirurgie
Mitglied- und Partnerschaften
  • Verbindung der Schweizer Ärztinnen und Ärzte (FMH)
  • Ärztegesellschaft des Kantons Zürich (AGZ)
  • Schweizerische Gesellschaft für Neurochirurgie (SGNC)
  • Deutsche Gesellschaft für Neurochirurgie (DGNC)
  • Deutsche Wirbelsäulengesellschaft (DWG)
  • Deutsche Akademie für Neurochirurgie (DANC/GANS)
  • Congress of Neurological Surgeons (CNS)
  • International Society on Minimal Invasive Neurosurgery (ISMINS)
  • Deutsche Krebsgesellschaft (DKG)
  • Kuratorium: „Friedhelm-Frees-Stiftung zur Förderung Minimal Invasive Neurochirurgie“
  • Vorstand: „Sabine-Dörges-Stiftung für krebskranke Kinder & Jugendliche“
Zusätzliche Aktivitäten

Aktuell

Ausrichtung regelmässiger internationaler Ausbildungskurse für endoskopische Neurochirurgie (>50: Zürich/CH, Berlin/D, /Budapest/HUN)

Tutor bei internationalen Ausbildungskursen für Schädelbasis- u. vasculäre Neurochirurgie (> 40: z.B. Strasbourg/F, Pittsburgh/USA)

Wissenschaftliche Vortragstätigkeit national/international (> 450)

Ausrichtung wissenschaftlicher Tagungen regional/national/international (23)

Geschäftsführer „Endomin-College“

Reviewer für die wissenschaftliche Zeitschriften (Central European Neurosurgery, Neurosurgical Review, Neurosurgery, World Neurosurgery, Aktuelle Neurologie)

Berater Fa. Karl Storz Endoskope, Tuttlingen/D

Entwicklung der wissenschaftlichen Datenbank „NeurOp-DAT“ für die Neurochirurgie

Beirat Fachbereich „Neurochirurgie/Hirnchirugie“ für den „Leading Medicine Guide“

Vormals

Ausrichtung des NCAFW zertifizierten jährlichen Trainingskurses „Kranielle Endoskopische Neurochirurgie“

Leiter Referat III „Fort- und Weiterbildung“ der Akademie für Aus-, Fort- und Weiterbildung (NCAFW) der DGNC und des BDNC

Editor-in-Chief des internationalen Journals “innovative Neurosurgery”

Editor-in-Chief des internationalen Journals “Minimal Invasive Neurosurgery”

Mitglied des wissenschaftlichen Beirats der „Aesculap Akademie“

Mitglied internationales Advisory Board „Neurosurgery“ der Fa. Aesculap/Tuttlingen/D

Mitglied internationales Advisory Board „Neuroendoscopy“ der Fa. Aesculap/Tuttlingen/D

Aufbau u. wissenschaftliche Leitung Neuroonkologisches Labor, NC Mainz/D

Aufbau u. wissenschaftliche Leitung Endoskopisch-mikrochirurgisches Labor, NC Mainz/D

Referenzarzt für Endoskopische & minimal-invasive Neurochirurgie der Fa. B.Braun/Aesculap/D und Richard Wolf/Knittlingen/D
Erfindungen und PatenteKinderendoskopie-System nach Hopf (Fa. Richard Wolf/Knittlingen/D)

Chirurgieassistenzsystem (Patentanmeldung Nr.: 10 2013 215 734.7)

Publikationen und Vorträge

Ausgewählte Originalarbeiten

Hopf NJ, Bremm J, Bohl J, Perneczky A (1994)
Image analysis of proliferating cells in tumors of the human nervous system: An immunohistological study using the monoclonal antibody Ki-67.
Neurosurgery 35: 917-923Hopf NJ, Füllbier L (2010)

Hopf NJ, Perneczky A (1998)
Endoscopic neurosurgery and endoscope-assisted microneurosurgery for the treatment of intracranial cysts.
Neurosurgery 43: 1330-1337

Grunert P, Müller-Forell W, Darabi K, Reisch R, Busert C, Hopf N, Perneczky A (1998)
Basic principles and clinical applications of neuronavigation and intraoperative computed tomography.
Computer Aided Surgery 3: 166-173

Hopf NJ, Grunert P, Fries G, Resch KDM, Perneczky A (1999)
Endoscopic third ventriculostomy: Outcome analysis of 100 consecutive procedures. Neurosurgery 44: 795-806

Hopf NJ, Grunert P, Darabi K, Busert C, Perneczky A (1999)
Frameless neuronavigation applied to endoscopic neurosurgery.
Minim Invas Neurosurg 42: 187-193

Hopf NJ (1999)
Endoscopic neurosurgery „around the corner“ with a rigid endoscope.
Minim Invas Neurosurg 42: 27-31

Kanner A, Hopf NJ, Grunert P (2000)
The „optimal“ burr hole position for endoscopic third ventriculostomy: results from 31 stereotactically guided procedures.
Minim Invas Neurosurg 43: 187-189

Demuth T, Hopf NJ, Kempski O, Sauner D, Herr M, Giese A, Perneczky A (2001)
Migration activity of human glioma cell lines in vitro assessed by continuous single cell observation.
Clin Exp Metastas 18: 589-597

Koch D, Grunert P, Filippi R, Hopf NJ (2002)
Re-ventriculostomy for treatment of obstructive hydrocephalus in cases of stoma dysfunction.
Minim Invasiv Neurosurg 45: 158-163

Iglesias JR, Hopf N (2005)
Histological heterogeneity of human glioblastomas investigated with an unsupervised neural network (SOM)
Histol Histopathol 20: 351-356

Hopf NJ, Stadie A, Reisch R (2009)
Management of bilateral middle cerebral artery aneurysms via a Unilateral Supraorbital
Key-Hole Craniotomy
Minim Invasiv Neurosurg 52: 126-131

Reisch R, Stadie A, Kockro R, Gawish I, Schwandt E, Hopf NJ (2009)
Supraorbital subfrontal key-hole approach for surgical treatment of temporomesial lesions of the dominant hemisphere
Minim Invasiv Neurosurg 52: 163-169

Hopf NJ, Füllbier L (2010)
Minimally invasive neurosurgery for vascular lesions.
Neurosurg Clin N Am 21(4): 673-689

Fischer G, Stadie A, Reisch R, Hopf NJ, Fries G, Böcher-Schwarz H, van Lindert E, Ungersböck K, Knosp E, Oertel J, Perneczky A (2011)
The keyhole concept in aneurysm surgery: results of the past 20 years.
Neurosurgery 68 (1 Suppl Operative):45-51; discussion 51.

Coburger J, Musahl C, Henkes H, Horvath-Rizea D, Bittl M, Weissbach C, Hopf N (2012)
Comparison of navigated transcranial magnetic stimulation and functional magnetic resonance imaging for preoperative mapping in rolandic tumor surgery
Neurosurg Rev 36: 65-75, discussion 75-76

Coburger J, Karhu J, Bittl M, Hopf NJ (2012)
First preoperative functional mapping via navigated transcranial magnetic stimulation in a 3-year-old boy.
J Neurosurg Pediatr 9 (6): 660-664

Reisch R, Stadie A, Kockro RA, Hopf N (2012)
The keyhole concept in Neurosurgery.
World Neurosurg 79 (2 Suppl); p. S17.e9-13 /201302/

Renovanz M, Kohlhof P, Nadji-Ohl M, Hopf N (2012)
Hirneigene Tumore
Nervenheilkunde 9:587-598

Nadji-Ohl M, Renovanz M, Hopf N (2012)
Therapieansätze in der Behandlung von Hirnmetastasen
Nervenheilkunde 9:607-614

Kurucz P, Baksa G, Patonay L, Hopf NJ (2013)
Endoscopic anatomical study of the arachnoid architecture on the base of the skull: Part I: The anterior and middle cranial fossa
Innovative Neurosurgery 1(1): 55-66

Kurucz P, Baksa G, Patonay L, Hopf NJ (2013)
Endoscopic anatomical study oft he arachnoid architecture on the base of the skull: Part II: Level oft he tentorium, posterior cranial fossa and the craniovertebral junction
Innovative Neurosurgery 1(2): 91-108

Hopf NJ, Kurucz P, Reisch R (2013)
Three-dimensional HD endoscopy – first experiences with the Einstein Vision system in neurosurgery
Innovative Neurosurgery 1(2): 125-131

Renovanz M, Gutenberg A, Haug M, Strittmacher E, Mazur J, Nadji-Ohl M, Giese A, Hopf N (2013)
Postsurgical screening for psychological disorders in neurooncological patients
Acta neurochirurgica; VOL: 155 (12); p. 2255-61 /201312/

Renovanz M, Hickmann A-K, Henkel C, Nadji-Ohl M, Hopf NJ (2014)
Navigated versus non-navigated intraoperative ultrasound: is there any impact on the extend of resection of high-grade gliomas? A retrospective clinical analysis.
J Neurol surg A 75: 224-230

Thaher F, Kurucz P, Fuellbier L, Bittl M, Hopf NJ (2014)
Endoscopic surgery for tumors of the pineal region via a paramedian infratentorial supracerebellar keyhole approach (PISKA)
Neurosurgical Review 37: 677-684

Hickmann A; Nadji-Ohl M; Hopf NJ (2014)
Feasibility of fluorescence-guided resection of recurrent gliomas using five-aminolevulinic acid: retrospective analysis of surgical and neurological outcome in 58 patients.
Journal of neuro-oncology /20150104/

Reisch R; Fischer G; Stadie A; Kockro R; Cesnulis E; Hopf N (2014)
The Supraorbital Endoscopic Approach for Aneurysms.
World neurosurgery; VOL: 82 (6S); p. S130-S137

Renovanz M; Hickmann AK; Gutenberg A; Bittl M; Hopf NJ (2015)
Does size matter? Minimally invasive approach in pediatric neurosurgery–a review of 125 minimally invasive surgeries in children: clinical history and operative results. Childs Nerv Syst. 2015;31(5):665-74

Hickmann A-K; Nadji-Ohl M; Haug M; Hopf NJ; Ganslandt O; Giese A; Renovanz M (2016)
Suicidal ideation, depression, and health-related quality of life in patients with benign and malignant brain tumors: a prospective observational study in 83 patients
Acta Neurochir; DOI 10.1007/s00701-016-2844-y

Bücher (Herausgeber)

Hopf NJ, Tonn J (Hrsg)
Neurochirurgische Akademie: Vaskuläre Neurochirurgie, Funktionelle Neurochirurgie
Georg Thieme Verlag Stuttgart-New York, 2011

Reisch R, Hopf N (Hrsg)
Transcranial Endoscope-Assisted Microsurgery: A practical Atlas
Aesculap AG

Ausgewählte Buchbeiträge

Hopf NJ, Resch KDM, Ringel K, Perneczky A:
Endoscopic Management of Intracranial Arachnoid Cysts.
In: Hellwig D, Bauer LB (edts): Minimally Invasive Techniques for Neurosurgery, Springer Verlag Berlin Heidelberg New York, pp: 111-119, 1998

Hopf NJ, Füllbier L:
Minimally invasive Neurosurgery for vascular lesions
In: Sughrue, Teo (Edts.): Neurosurgery Clinics of North America: Minimally Invasive Intracranial Surgery, Elsevier Verlag New York, 2010

Hopf NJ:
Nichtrupturierte Aneurysmen: Zeitbombe im Kopf
In: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Steiger H-J, Hopf NJ:
Arteriovenöse Malformationen: Klassifikation
in: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Musahl C, Schul C, Hopf NJ:
Intraoperative Indozyaningrün (ICG)-Fluoreszenzangiographie „IR 800“ der Firma ZEISS
in: Hopf, Tonn (Hrsg): Neurochirurgische Akademie: Vaskuläre Neurochirurgie, funktionelle Neurochirurgie, Thieme Verlag Stuttgart New York, 2011

Hopf NJ, Musahl C, Henkes H:
Carotid Cavernous Fistulas: Part I: Presentation and Features
in: Spetzler, Kalani, Nakaji (Hrsg): Neurovascular Surgery, 2nd Edition,
Thieme Verlag Stuttgart – New York, 2015

Musahl C, Weissbach C, Hopf NJ:
Neuromonitoring
in: Spetzler, Kalani, Nakaji (Hrsg): Neurovascular Surgery, 2nd Edition,
Thieme Verlag Stuttgart – New York, 2015

Musahl C and Hopf NJ:
Neuromonitoring for arteriovenous malformation surgery
in: Spetzler RF, Kondziolka DS, Higashida RT, Kalani MYS: Comprehensive Management of Arteriovenous Malformations of the Brain and Spine
Cambridge University Press, 2015

Hopf NJ, Reisch R, P Kurucz:
Neurovascular Compression Syndromes
in: König A, Spetzger U: Skull Base Surgery – Schädelbasischirurgie
Springer-Verlag, Heidelberg, 2018

Hopf NJ and Gardner PA:
Intracranial Aneurysms
in: Evans JJ, Kenning TJ, Farrell C, Kshettry V (Hrsg): Endoscopic and Keyhole Cranial Base Surgery
Springer International Publishing, 2019

Hopf N, Reisch R:
Skull Base Approaches: Supraorbital
in: Raabe A (Hrsg): The Craniotomy Atlas
Thieme Verlag Stuttgart, 2019

Hopf NJ.
Tumors of the anterolateral skull base: anterior clinoid: Perspective
in: Jean W (Hrsg): Skull base surgery: strategies
Thieme Publishers New York, 2019

Musahl C, Hopf NJ:
Neuromonitoring for brainstem surgery
in: Spetzler, Kalani, Lawton (Hrsg): Surgery of the brainstem
Thieme Verlag New York, 2019

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